Inclusion-Body Myositis

Inclusion-body myositis (IBM) is found in more men than women with onset usually occurring after age 50. A small number of IBM cases may be hereditary (h-IBM) but most are "sporadic" (s-IBM) meaning there is not a direct genetic link. In most cases, IBM progresses slowly over months or years. There is currently no effective treatment for IBM, although current gene therapy trials supported by TMA show promise.

Signs and symptoms


  • Frequent falling episodes
  • Trouble climbing stairs or standing from a seated position
  • A foot that seems to drop when walking, causing tripping
  • Weakened hand grip
  • Difficulty swallowing


  • Weakness and noticeable shrinking of the quadriceps (main muscle of the thighs), causing falls
  • Weakness in the forearm muscles
  • Weakness of muscles below the knees, causing the foot to drop and toes to catch when walking
  • Weakness of flexor muscles of the fingers used for gripping
  • Weakness of throat muscles, causing trouble swallowing (dysphagia) and possibly choking
  • Pain or discomfort as muscles weaken



Updated March 2012




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